Mavorixafor (mav-or-IX-a-for)

Used to increase white blood cells in patients with an immune system problem called WHIM syndrome (warts, hypogammaglobulinemia, infections, and myelokathexis).

Brand Name(s):

Xolremdi

When This Medicine Should Not Be Used:

How to Use This Medicine:

Capsule

• Your doctor will tell you how much medicine to use. Do not use more than directed.
• Swallow the capsule whole. Do not open, break, or chew it.
• It is best to take this medicine on an empty stomach after an overnight fast and at least 30 minutes before a meal.
• Missed dose: If you miss a dose, skip the missed dose and go back to your regular dosing schedule. Do not take an extra dose.
• Store this medicine in the refrigerator. Do not freeze.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• Do not use this medicine together with dextromethorphan.
• Some food and medicines can affect how mavorixafor works. Tell your doctor if you are using digoxin, metformin, midazolam, medicines that cause heart rhythm problems, or supplements that contain goldenseal or St John's wort.
• Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

Warnings While Using This Medicine:

• It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant. If you are a woman who can get pregnant, your doctor may do tests to make sure you are not pregnant before receiving this medicine. Use an effective form of birth control to keep from getting pregnant during treatment with this medicine and for 3 weeks after the last dose.
• Do not breastfeed during treatment with this medicine and for 3 weeks after the last dose.
• Tell your doctor if you have kidney disease, liver disease, or heart rhythm problems.
• This medicine can cause a change in heart rhythm called QT prolongation.
• Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
• Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Fainting, dizziness, lightheadedness
• Fast, pounding, or uneven heartbeat
• Unusual bleeding, bruising, or weakness

If you notice these less serious side effects, talk with your doctor:

• Runny or stuffy nose, nosebleeds
• Rash
• Vomiting

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088