Futibatinib (fue-ti-BA-ti-nib)

Treats bile duct cancer.

Brand Name(s):

Lytgobi 12MG Daily Dose, Lytgobi 16MG Daily Dose, Lytgobi 20MG Daily Dose

When This Medicine Should Not Be Used:

How to Use This Medicine:

Tablet

• Take your medicine as directed. Your dose may need to be changed several times to find what works best for you. Take it about the same time each day.
• Swallow the tablet whole with water. Do not crush, chew, split, or dissolve it.
• Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
• Missed dose: If it is within 12 hours on the same day, take it as soon as you remember. If it is more than 12 hours have passed, skip the missed dose and go back to your regular dosing schedule. If you vomit after taking your medicine, do not take an extra dose.
• Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• Some medicines can affect how futibatinib works. Tell your doctor if you are using itraconazole or rifampin.
• Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

Warnings While Using This Medicine:

• It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant. If you are a woman who can get pregnant, your doctor may do tests to make sure you are not pregnant before starting treatment. Use an effective form of birth control during treatment and for at least 1 week after the last dose. Male patients with female partners should use an effective form of birth control during treatment and for at least 1 week after the last dose.
• Do not breastfeed during treatment and for at least 1 week after the last dose.
• Tell your doctor if you have eye or vision problems.
• This medicine may cause eye or vision problems, including dry or swollen eyes. You may use artificial tear substitutes, hydrating, or lubricating eye gels to help prevent or treat dry eyes.
• Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
• Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
• Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Blurred vision or changes in vision, dry eyes
• Bone pain, trouble breathing, unusual tiredness or weakness
• Constipation, diarrhea, loss of appetite, nausea, vomiting
• Numbness and tingling around the mouth, fingertips, or feet
• Redness, swelling, pain, ulcers, or scaling of the skin on the hands and feet
• Sores or white patches on your lips, mouth, or throat
• Stomach pain or cramps, confusion, seizures, uneven heartbeat, mood or mental changes

If you notice these less serious side effects, talk with your doctor:

• Changes in fingernails or toenails
• Dry skin
• Hair loss
• Joint, arm, or leg pain
• Loss of taste, changes in taste, dry mouth

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088