Belinostat (be-LIN-oh-stat)

Treats peripheral T-cell lymphoma.

Brand Name(s):

Beleodaq

When This Medicine Should Not Be Used:

How to Use This Medicine:

Injectable

• Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
• You will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine.
• Your doctor will prescribe your dose and schedule. This medicine is given through an IV placed in a vein.
• Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Warnings While Using This Medicine:

• It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant. Women should not get pregnant for at least 6 months after treatment ends. Men should not father a child for at least 3 months after treatment ends.
• Do not breastfeed during treatment and for at least 2 weeks after the last dose.
• Tell your doctor if you have liver disease, anemia, low white blood cell or platelet count, or an infection.
• This medicine may cause the following problems:
  • Liver problems
  • Tumor lysis syndrome
• This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.
• If you plan to have children, talk with your doctor before using this medicine. Some men using this medicine have become infertile (unable to have children).
• Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Change in how much or how often you urinate, lower side or back pain, joint pain or swelling
• Dark urine or pale stools, nausea, vomiting, loss of appetite, yellow skin or eyes
• Fast, pounding, or uneven heartbeat, dizziness, lightheadedness
• Fever, chills, cough, sore throat, and body aches
• Rapid weight gain, swelling of the feet or lower legs
• Unusual bleeding, bruising, or weakness

If you notice these less serious side effects, talk with your doctor:

• Mild nausea, vomiting, diarrhea, constipation
• Pain, burning, or swelling where the needle is placed
• Tiredness

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088