Canakinumab (kan-a-KIN-ue-mab)

Treats cryopyrin-associated periodic syndromes (CAPS), tumor necrosis factor receptor associated periodic syndrome (TRAPS), hyperimmunoglobulin D syndrome (HIDS)/mevalonate kinase deficiency (MKD), familial Mediterranean fever (FMF), gout flares, and Still's disease, including adult-onset Still's disease (AOSD) and systemic juvenile idiopathic arthritis (SJIA).

Brand Name(s):

Ilaris

When This Medicine Should Not Be Used:

How to Use This Medicine:

Injectable

• Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot under your skin.
• A nurse or other health provider will give you this medicine.
• This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• Some medicines can affect how canakinumab works. Tell your doctor if you are using any of the following:
  • Adalimumab, anakinra, certolizumab, etanercept, golimumab, infliximab, rilonacept
  • Blood thinner (including warfarin)
  • Cancer medicine
  • Steroid medicine
• This medicine may interfere with vaccines. Ask your doctor before you get a flu shot or any other vaccines.

Warnings While Using This Medicine:

• Tell your doctor if you are pregnant or breastfeeding, or if you have liver disease (including hepatitis B or C), an immune system problem (including HIV or AIDS), any type of infection, or an infection that keeps coming back.
• This medicine may cause the following problems:
  • Increased risk for infections
  • Increased risk for cancer
  • Macrophage activation syndrome, a life-threatening condition
• You will need to have a skin test for tuberculosis (TB) before you start receiving this medicine. Tell your doctor if you or anyone in your home has ever had a positive reaction to a TB test.
• Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Back, joint, or muscle pain
• Change in how much or how often you urinate, bloody or cloudy urine, lower back or side pain
• Fever, chills, cough, sore throat, stuffy or runny nose, body aches
• Nausea, diarrhea, stomach pain
• Redness in one part of your body, warm feeling or swelling of your skin
• Trouble breathing or swallowing

If you notice these less serious side effects, talk with your doctor:

• Dizziness, or the feeling of spinning or constant movement
• Headache
• Pain, itching, burning, swelling, or a lump under your skin where the shot was given
• Weight gain

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088