Tipranavir (tye-PRAN-a-vir)

Treats HIV infection. This medicine does not cure HIV or AIDS, but it may help slow down the progress of the disease. It is given in combination with ritonavir.

Brand Name(s):

When This Medicine Should Not Be Used:

How to Use This Medicine:

Capsule

• Your doctor will tell you how much medicine to use. Do not use more than directed.
• It is best to take this medicine with food or milk.
• Swallow the capsule whole. Do not open or chew it.
• Contact your doctor or pharmacist when your supply of this medicine is low. Do not allow yourself to run out of this medicine.
• Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
• Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
• Store the capsules in the refrigerator until you are ready to open the bottle. Once you have opened the medicine bottle, you may store it at room temperature, away from heat, light, or moisture. The medicine is good for up to 60 days after you open the bottle. Throw away any unused capsules after 60 days and get a new bottle of medicine.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• Do not use this medicine if you are also using alfuzosin, amiodarone, bepridil, cisapride, dihydroergotamine, ergonovine, ergotamine, flecainide, lovastatin, lurasidone, methylergonovine, midazolam, pimozide, propafenone, quinidine, rifampin, sildenafil, simvastatin, St John's wort, or triazolam.
• Do not use this medicine together with colchicine if you have kidney or liver disease.
• There are many other drugs that can interact with lopinavir/ritonavir. Tell your doctor about all other medicines you are using.
• Birth control pills may not work as well to prevent pregnancy when used with this medicine. Use another form of birth control (including condoms or spermicide) along with your pills.

Warnings While Using This Medicine:

• Tell your doctor if you are pregnant or if you have liver disease (including hepatitis B or C), bleeding problems, diabetes, high cholesterol, or hemophilia. Tell your doctor if you are allergic to sulfa drugs.
• Do not breastfeed. You can spread HIV or AIDS to your baby through your breast milk.
• This medicine may cause the following problems:
  • Liver problems
  • Increased risk for bleeding, including intracranial hemorrhage
  • High blood sugar levels
  • High cholesterol or triglycerides
• Your immune system may get stronger when you start taking HIV medicines. This could cause a hidden infection in your body to become active. Tell your doctor right away if you notice any changes in your health.
• Always practice safe sex, even if your partner also has HIV. If you stop taking this medicine or do not take it as prescribed, you may spread HIV to others. Do not reuse or share needles, or other items, that may have blood or body fluids on them.
• This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.
• Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
• Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Blistering, peeling, red skin rash
• Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
• Increased hunger or thirst, change in how much or how often you urinate, unusual weight loss
• Sudden or severe headache, or problems with vision, speech, or walking
• Unusual bleeding, bruising, or weakness

If you notice these less serious side effects, talk with your doctor:

• Diarrhea
• Weight gain around your neck, upper back, breast, face, or waist

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088