Antithymocyte Globulin Rabbit (an-tye-THYE-moe-site GLOB-ue-lin RAB-it)

Prevents and treats your body from rejecting a transplanted kidney.

Brand Name(s):

Thymoglobulin

When This Medicine Should Not Be Used:

How to Use This Medicine:

Injectable

• Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.
• A nurse or other health provider will give you this medicine.
• You may be given other medicines at least 1 hour before you receive this medicine to help prevent infusion reactions.
• Missed dose: Call your doctor or pharmacist for instructions.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• Some medicines can affect how this medicine works. Tell your doctor if you are using medicines that weaken your immune system, including steroids, cancer medicine, or radiation treatment.
• This medicine may interfere with vaccines. Ask your doctor before you get a flu shot or any other vaccines.

Warnings While Using This Medicine:

• Tell your doctor if you are pregnant or breastfeeding, or if you have liver disease or an infection.
• This medicine may cause the following problems:
  • Infusion-associated reactions
  • Increased risk of cancer, including lymphoma
• This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.
• Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Bloody or cloudy urine, difficult, burning, or painful urination, lower back or side pain
• Chest pain, trouble breathing
• Confusion, weakness, trouble breathing, numbness or tingling in hands, feet, or lips
• Fast or slow, pounding heartbeat, or uneven heartbeat
• Fever, chills, cough, sore throat, body aches
• Unusual bleeding, bruising, weakness

If you notice these less serious side effects, talk with your doctor:

• Constipation, diarrhea, nausea, vomiting, or stomach pain
• Headache, trouble sleeping
• Joint or muscle pain
• Pain, itching, burning, redness, swelling, or a lump under your skin where the needle is placed

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088